DeSmuME is a Nintendo DS emulator that enables you to play games on your PC by downloading DS ROM files from the Internet.
You may use DeSmuME for Windows 64bit to imitate a Nintendo DS device. Consider it a Swiss-Army knife for Nintendo DS emulation, with numerous useful capabilities for testing DS functionality, such as checking ROM characteristics and controlling Action Replay cheats. The great part is that this program is entirely free and open-source.
Since we first saw that large white and grey block at the turn of the century, the GameBoy has gone a long way. The Nintendo DS, its great, great, great-grandchild, is now even more powerful than the high-tech arcade machines of the early 1990s. It's so nice, in fact, that you'll want to play with it at work, which you clearly can't. You can, in fact, do so. You can't, in fact. You can, kind of, use DeSmuME. Allow us to clarify...
The first thing you should know is that downloading DS ROM files is illegal, so you're on your own if the FBI shows up at your door. Aside from the legalities, DeSmuME is an excellent emulator that was initially developed for game creators to test and improve their newest projects. DeSmuME is a bit complicated to set up, but once it's up and running, you'll be able to play a vast variety of ROM games.
DeSmuME is the most well-known open-source Nintendo DS emulator for desktop computers. It includes tools for hacking, speedrunning, YouTubers, and casual gamers.GDB supports homebrew applications and even allows them to be debugged.
Both the Windows and macOS versions have a lot of features, and there's a tiny community of forks and modifications that add even more for casual play.
With the noteworthy exception of DraStic, DeSmuME for PC is the genesis of RetroArch and OpenEmu Nintendo DS compatibility and is utilized by various mobile Nintendo DS emulators.